![]() Therapeutic control of complement activation at the level of the central component C3. The role of complement in the mechanism of action of therapeutic anti-cancer mAbs. Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement. This study provided structural insights into the activation of the classical pathway by hexameric antigen–IgG complexes. ![]() Complement is activated by IgG hexamers assembled at the cell surface. Manipulating the mediator: modulation of the alternative complement pathway C3 convertase in health, disease and therapy. A journey through the lectin pathway of complement-MBL and beyond. Toward a structure-based comprehension of the lectin pathway of complement. Complement - tapping into new sites and effector systems. Complement system part I - molecular mechanisms of activation and regulation. Complement: a key system for immune surveillance and homeostasis. Ricklin, D., Hajishengallis, G., Yang, K. The complement cascade repurposed in the brain. Proteolytic cascades and their involvement in invertebrate immunity. Complement in disease: a defence system turning offensive. Novel mechanisms and functions of complement. We thus highlight major therapeutic concepts and milestones in clinical complement intervention. The pervasive contribution of complement to disease pathophysiology has inspired a resurgence of complement therapeutics with major clinical developments, some of which have challenged long-held dogmas. Despite its tight spatiotemporal regulation, complement activation can be derailed, fuelling inflammatory tissue pathology. It highlights illustrative paradigm shifts that have reshaped our understanding of complement pathobiology, drawing examples from evolution, development of the central nervous system, tissue regeneration and cancer immunity. This Review provides a guide to the system-wide functions of complement. ![]() Besides modulating host–pathogen interactions, this crosstalk guides early developmental processes and distinct cell trajectories, shaping tissue immunometabolic and regenerative programmes in different physiological systems. Complement engages in intricate crosstalk with multiple pattern-recognition and signalling pathways both in the extracellular and intracellular space. Yet, growing evidence has illuminated a broader involvement of complement in fundamental biological processes extending far beyond its traditional realm in innate immunity. Irish funding provides emergency humanitarian assistance to the most vulnerable, while also supporting the Palestinian Authority to deliver basic public services.Complement has long been considered a key innate immune effector system that mediates host defence and tissue homeostasis. In a hasty clarification also posted on X, the EU’s crisis management commissioner Janez Lenarčič announced that EU humanitarian aid to Palestinians “will continue as long as needed” and that it was “imperative to protect civilians” even while condemning Hamas.Īustria and Germany have already announced they would suspend payments of bilateral aid to Palestinians amid revulsion at the attack, which killed 800 people including 260 revellers at a rave party, leading to pressure on the European Commission to follow suit.įour out of five Palestinians are dependent on international assistance for basic human needs, and the Department of Foreign Affairs has said it remains committed to delivering support to Palestinian civilians that their needs should be a central part of the overall response to this crisis by the international community. The decision also drew criticism from Luxembourg, Belgium, and Spain, while the European Commission was pummelled by questions from journalists about why its policy appeared to have suddenly shifted and whether humanitarian aid was included in the freeze. The announcement caused shock among NGOs that work in the region, to which the EU and its member states are major donors, and raised fears of compounding a humanitarian crisis as Israel declared a “complete siege” on Gaza that would cut off electricity, food, water, and gas.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |